Nevertheless, there are studies that predict post-transplant survival using the model for end-stage liver disease (MELD) score ( 4- 6). There are also variables independent of pretransplant factors, such as level of surgical skill, adverse events in the perioperative period, graft rejection, and biliary and vascular complications. It is very important to identify pretransplant risk factors for early mortality, but it is difficult to create a model for predicting post-transplant outcomes based on pretransplant variables. reported that 30-day mortality and 1-year mortality for DDLT were 30%, and 39% respectively in their study ( 3). LT has a 30-day mortality of about 5–10% ( 3), and Jo et al. HE is reversible in patients with no neurological or metabolic abnormalities ( 1), but liver transplantation (LT) is a definitive treatment for HE ( 2). Hepatic encephalopathy (HE) is a serious complication of non-compensated end-stage liver disease and exhibits a wide range of neuropsychiatric abnormalities ranging from subtle psychological alterations to coma. Keywords: End stage liver disease hepatic encephalopathy (HE) liver transplantation (LT) mortality survival Although prospective validation should be conducted to determine the prognostic value of HE severity, efforts could be made to reduce the severity of HE before DDLT, and consider severity of HE rather than MELD score in DDLT allocation. In addition, the severe HE group significantly decreased survival compared to the non-HE group, and the cumulative 1- and 3-year overall survival rates were 80.9% and 78.7%, respectively, in non HE group, and 65.7% and 56.1%, respectively, in severe HE group (P=0.031).Ĭonclusions: Severe HE is a factor influencing the long-term survival over 3 years in the patients who underwent DDLT. Results: Presence of HE is not statistically associated to patient survival (P=0.062), but the hazard ratio is 1.954 (95% CI, 0.968, 3.943). Methods: The medical records of adult patients who underwent deceased donor LT (DDLT) were retrospectively reviewed for analysis of the effect of HE on the long-term survival rate of post-transplant for more than 1 year.
MELD does not take into account individual complications such as hepatic encephalopathy (HE), and research has shown that the greater the severity of pretransplant HE, the lower the survival rate after LT the importance of monitoring for HE is therefore emphasized. It is not easy to create a model for predicting post-transplantation outcomes based on pretransplant variables. reported that 30-day mortality and 1-year mortality for DDLT were 30%, and 39% respectively. Policy of Dealing with Allegations of Research Misconductīackground: Liver transplantation (LT) has the incidence of 30-day mortality about 5–10%, Jo et al.Policy of Screening for Plagiarism Process.
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